Synarel Nasal Spray (Nafarelin Acetate)

Do’s

• Before starting to use Synarel nasal spray, read the Medication Guide provided by your pharmacist. If available, also read the Patient Information Leaflet. 
• Follow the illustrated directions provided with the medication for the proper use of Synarel nasal spray. If you have any questions, consult your healthcare provider for clarification.
• If you are using a new bottle of Synarel nasal spray for the first time, follow the instructions for test sprays in the air. A fine mist indicates that the spray is working properly.
• Gently blow your nose before using Synarel nasal spray. For very young children, it may be necessary to clear the nose with a bulb syringe.
• Use Synarel nasal spray as directed by your healthcare provider, usually twice daily, with approximately 12 hours between each dose.
• If you need to use more than one spray at a time, wait for 30 seconds between each spray. 
• Clean the spray tip after each use. Follow the detailed instructions provided for cleaning the spray tip.
• The dosage and length of treatment with Synarel nasal spray will be determined by your healthcare provider based on your medical condition and response to treatment. Use the medication exactly as prescribed.
• Consult your healthcare provider to determine how long each bottle of Synarel nasal spray should last.
• If you need to use a nasal decongestant spray while using Synarel nasal spray, wait at least 2 hours after using Synarel before using the decongestant.
• When starting Synarel nasal spray, you may experience an initial worsening of symptoms (such as increased vaginal bleeding in women with endometriosis or certain symptoms for children with early puberty). These symptoms should improve after the first month of treatment. If your symptoms do not improve or worsen after 2 months of treatment, inform your healthcare provider.

Don’ts

• Avoid spraying the medication in your eyes. Additionally, try to avoid sneezing during or immediately after using Synarel nasal spray, as this may reduce the amount of medication absorbed.
• Do not skip any doses.
• Do not use the nasal spray bottle longer than recommended, even if there is medication left over, as you may not receive a full dose. Make sure to get your medication refills a few days early to avoid running out.
• Do not increase your dose or use Synarel nasal spray more frequently or for a longer duration than prescribed by your healthcare provider. It will not improve your condition faster and may increase the risk of side effects.

Common Side Effects

• Nasal irritation
• Congestion
• Runny nose
• Sneezing
• Headache
• Altered taste

Less Common Side Effects:

• Hot flashes
• Mood changes
• Vaginal dryness
• Breast tenderness
• Decreased libido
• Acne

Rare but Serious Side Effects:

• Allergic reactions
• Severe nasal irritation or bleeding
• Worsening of symptoms in conditions such as endometriosis or early puberty

This is not an exhaustive list of side effects, and individual experiences may vary. Consult with your healthcare provider for a complete list of potential side effects and discuss any concerns you may have. 

Prolonged use of Synarel may lead to a small loss of trabecular bone mineral content. Although this is mostly reversible within 6 months of stopping treatment, it is not recommended to use Synarel for longer than 6 months without consulting your healthcare provider. 

Ovarian cysts have been reported to occur in the first two months of therapy with Synarel. While most of these cystic enlargements resolve spontaneously, some cases may require discontinuation of the drug or surgical intervention. Inform your healthcare provider if you experience any unusual symptoms.

If you become pregnant during treatment with Synarel, the administration of the drug must be discontinued. Inform your healthcae provider, as there may be a potential risk to fetal development and/or miscarriage. 

This is not an exhaustive list of warnings and precautions. Consult with your healthcare provider for comprehensive information and personalized advice.