Matulane (Procarbazine)

Do’s

• Take Matulane exactly as prescribed by your healthcare provider, typically once or twice daily.
• Take Matulane consistently, even if you experience nausea.
• Contact your healthcare provider if you vomit soon after taking a dose.
• Follow your healthcare provider's instructions regarding dose and treatment cycles (typically taken for 2 weeks, then stopped for a period before repeating).
• Be patient with treatment. It may take time to see results.

Don'ts

• Don't adjust your dosage without consulting your healthcare provider.
• Don't stop taking Matulane abruptly, even if you feel better.
• Don't chew or crush them. Swallow the capsules whole
• Do not stop taking Matulane. If you vomit soon after taking a dose, contact your doctor right away for instructions.

Common Side Effects:

• Loss of appetite
• Stomach pain (upper right side)
• Tiredness
• Itching
• Dark urine
• Clay-colored stools
• Nausea
• Vomiting
• Muscle or joint pain
• Nervousness
• Other common side effects may also occur, but this is not a complete list.

Serious Side Effects:

• Low blood cell counts, which may manifest as fever, chills, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed, or shortness of breath
• Liver problems, indicated by symptoms such as loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes)
• Increased risk of bleeding or infection, with symptoms including unusual bruising or bleeding, or new signs of infection (fever, chills, mouth sores, pale skin)
• Serious allergic reactions, although rare, may include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Matulane,  contact your healthcare provider for medical advice.

Inform your healthcare provider if you are allergic to procarbazine or any other ingredients in Matulane.

Disclose any pre-existing medical conditions to your healthcare provider before using Matulane, especially:

• Bleeding problems
• Current or recent infections
• Kidney disease
• Liver disease
• History of radiation treatment

Matulane may cause dizziness or drowsiness. Avoid driving, operating machinery, or activities requiring alertness until you are sure you can do them safely. Don't drink alcohol or use marijuana while taking Matulane.

Avoid alcohol and products containing alcohol while taking Matulane as it can cause severe stomach upset.

Smoking increases the risk of lung cancer while using Matulane. Quit smoking or discuss alternatives with your healthcare provider.

Matulane can increase sun sensitivity. Limit sun exposure, use sunscreen, and wear protective clothing outdoors.

Matulane can weaken your immune system and make you more susceptible to infections. Avoid people with contagious illnesses and discuss any potential exposure with your healthcare provider.

Inform your healthcare provider about Matulane use before getting any vaccinations. Avoid contact with people who recently received live vaccines.

Be cautious with sharp objects and avoid contact sports to minimize the risk of cuts, bruises, or injuries.

Tell your healthcare provider about all medications you take, including Matulane, before having surgery.

Children may be more sensitive to side effects like tremors, loss of consciousness, or seizures.

Procarbazine can harm an unborn baby. Discuss birth control methods with your healthcare provider while using Matulane. If you become pregnant, talk to your healthcare provider about the risks and benefits of this medication. 

It is unknown if Matulane passes into breast milk, so breastfeeding is not recommended.