Jardiance (Empagliflozin)

Please read the instructions before using Jardiance film coated tablets. Do's

• Take Jardiance exactly as your healthcare provider tells you to take it.
• Take Jardiance by mouth 1 time in the morning each day, with or without food.
• Your healthcare provider may change your dose if needed.
• If you miss a dose, take it as soon as you remember. If you do not remember until it is time for your next dose, skip the missed dose and go back to your regular schedule.
• Your healthcare provider may tell you to take Jardiance along with other diabetes medicines. Low blood sugar can happen more often when Jardiance is taken with certain other diabetes medicines.
• If you take too much Jardiance, call your healthcare provider or go to the nearest hospital emergency room right away.

Don'ts

• Do not take two doses of Jardiance at the same time. Talk with your healthcare provider if you have questions about a missed dose.

Common Side Effects:

• Bladder pain
• Bloody or cloudy urine
• Change in the color, amount, or odor of vaginal discharge
• Difficult, burning, or painful urination
• Frequent urge to urinate
• Itching, stinging, or redness of the vaginal area
• Lower back or side pain
• Pain during sexual intercourse
• Mild urinary tract infection (UTI)
• Mild genital yeast infection
• Urinating more often than usual
• Increased urination
• Elevated levels of fats or cholesterol in the blood
• Joint pain
• Nausea
• Kidney problems

Less Common Side Effects:

• Discharge with a strong odor from the penis

Serious Side Effects:

• Dehydration, with symptoms such as feeling dizzy or lightheaded
• Low blood pressure
• Low blood sugar
• Ketoacidosis (too much acid in the blood)
• Acute kidney impairment or injury
• Allergic reactions 

This is not an exhaustive list of side effects, and other side effects may occur. If you experience any unusual symptoms or side effects while taking Jardiance, seek medical advice promptly.

Always consult your healthcare provider for personalized information and guidance regarding the potential side effects of Jardiance.

Jardiance can cause intravascular volume contraction and may lead to renal impairment. There have been reports of acute kidney injury, some requiring hospitalization and dialysis, in patients receiving SGLT2 inhibitors, including Jardiance. 

Patients should be assessed for signs and symptoms of metabolic acidosis for ketoacidosis, regardless of blood glucose level. Before initiating Jardiance, consider risk factors for ketoacidosis. Patients on Jardiance may require monitoring and temporary discontinuation of therapy in clinical situations known to predispose to ketoacidosis.

Symptomatic hypotension may occur with Jardiance, and patients should be advised to maintain adequate fluid intake to reduce the risk of hypotension.

Jardiance may lead to serious genital infections, such as necrotizing fasciitis of the perineum. Patients should promptly seek medical attention if they develop symptoms such as pain or tenderness, redness, or swelling of the genitals or the area from the genitals back to the rectum, along with a fever above 100.4°F or malaise.

Jardiance may interact with other medications, such as diuretics, potentially affecting blood pressure and blood sugar levels. Discuss potential interactions with a healthcare provider.

Jardiance is not suitable for individuals with severe or end-stage kidney disease, those on dialysis, or those with known hypersensitivity to empagliflozin. It is also not recommended for use in patients with Type 1 diabetes or diabetic ketoacidosis.

Consult a healthcare provider for personalized advice and to thoroughly discuss any potential risks or concerns before starting Jardiance.

What should I tell my healthcare provider before taking Jardiance? Before starting Jardiance, let your doctor know about any health conditions you have, including if you:

• Have kidney or liver problems.
• Have had infections in the vagina or penis.
• Have a history of urinary tract infections or trouble urinating.
• Are scheduled for surgery. Your doctor may ask you to stop taking Jardiance before surgery and will let you know when to start it again.
• Are eating less or have recently changed your diet.
• Have had issues with your pancreas, such as pancreatitis or surgery on your pancreas.
• Drink alcohol often or binge drink.
• Have type 1 diabetes—Jardiance is not meant for people with type 1 diabetes.
• Are pregnant or planning to become pregnant. Jardiance may harm your baby, so talk to your doctor about how to manage your blood sugar safely during pregnancy.
• Are breastfeeding or planning to breastfeed. Jardiance can pass into breast milk and may harm your baby. Do not breastfeed while taking this medication.

Other Medications Tell your doctor about all the medicines, vitamins, and herbal supplements you take, including those bought over the counter. Some medicines can change how Jardiance works, and Jardiance may also affect other medications. Be sure to mention if you take:

• Diuretics (water pills)
• Insulin or other medications that lower blood sugar

Keep a list of your medications and share it with your doctor or pharmacist when starting a new one.

References

• 2022. Prescribing Information and Medication Guide. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/204629s033lbl.pdf
• 2023. Prescribing Information and Medication Guide. Boehringer Ingelheim. https://patient.boehringer-ingelheim.com/us/products/jardiance/
• 2024. Medication Guide. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=faf3dd6a-9cd0-39c2-0d2e-232cb3f67565

Generic name:	Empagliflozin, Empagliflozin
Formulation:	Film Coated Tablet
Strength(s):	10mg, 25mg
Quantities Available:	30, 60, 90, 100, 180