Cosopt (Dorzolamide/Timolol)

Please read the instructions before using Cosopt Eye Drops. Follow your doctor's prescription exactly. Use 1 drop of Cosopt (dorzolamide/timolol) in the affected eye or both eyes twice daily—once in the morning and once in the evening. If you use another eye drop, wait at least 5 minutes before or after applying this eye drop. If you wear soft contact lenses, remove them before using Cosopt. You can put them back in 15 minutes after applying the drops. Avoid touching your eye or eyelid with the dropper tip to prevent contamination. Contaminated eye drops can cause infections that may lead to vision loss. If you suspect contamination or develop an eye infection, contact your doctor immediately. If you have eye surgery, an eye injury, or an infection, ask your doctor if you should keep using Cosopt. In case of overdose, you may experience dizziness, headaches, slow heartbeat, shortness of breath, or breathing problems. If you have these symptoms, seek medical help right away.

Ingredients

Active ingredients: Dorzolamide 20 mg/mL (2%) and Timolol 5 mg/mL (0.5%) Inactive ingredients: Information about inactive ingredients is not available in the provided document.

Common Side Effects: Cosopt (dorzolamide/timolol) may cause mild eye discomfort, including burning, stinging, redness, itching, tearing, and blurred vision. Some people may notice a bitter or sour taste after using the drops. Serious Side Effects: In rare cases, Cosopt may cause severe breathing problems, heart failure, serious sulfa reactions, increased allergic reactions, worsening muscle weakness, or eye swelling. Seek medical help immediately if you experience these symptoms. This is not a complete list of possible side effects. For a full list, ask your doctor or pharmacist.

Do not use Cosopt (dorzolamide/timolol) if you have or have had asthma, chronic obstructive pulmonary disease (COPD), or severe breathing problems. Avoid this medication if you have heart conditions such as a slow heartbeat, heart block, heart failure, or cardiogenic shock. Do not use COSOPT if you are allergic to any of its ingredients.

Before Using Cosopt

Tell your doctor if you have allergies to sulfa drugs, a history of severe allergic reactions, or atopy. Inform your doctor if you have muscle weakness, myasthenia gravis, diabetes, thyroid disease, or kidney or liver problems. Let them know if you plan to have surgery, wear contact lenses, use other eye drops, or have an eye infection or injury. If you are pregnant or breastfeeding, talk to your doctor before using Cosopt. It is unclear if the medication affects an unborn baby or passes into breast milk.

Cosopt (Dorzolamide/Timolol) Drug Interactions

1. Oral Carbonic Anhydrase Inhibitors: Taking Cosopt with these medications may increase systemic carbonic anhydrase inhibition. This combination is not recommended.
2. High-Dose Salicylate Therapy: Using Cosopt with high-dose aspirin or similar drugs may cause acid-base and electrolyte imbalances.
3. Calcium Channel Blockers: Combining Cosopt with drugs like amlodipine or diltiazem may lead to low blood pressure, slow heart rate, or heart failure.
4. Catecholamine-Depleting Drugs: These medications, like reserpine, may cause similar effects as calcium channel blockers, leading to low blood pressure and slow heart rate.
5. Beta-Blockers: Taking Cosopt with other beta-blockers, such as metoprolol or propranolol, may intensify systemic beta-blockade.
6. Quinidine: This drug can enhance Cosopt’s beta-blocking effects, increasing the risk of slow heart rate and low blood pressure.
7. Clonidine: Using clonidine with Cosopt is usually not advised due to potential complications.

Always inform your healthcare provider about all medications you take to avoid harmful interactions.

How should I store Cosopt?

• Store at 68° to 77°F (20° to 25°C) F (20° to 25°C).
• Protect from light.
• Do not use this drug after the expiration date on the bottle.
• Keep Cosopt and all medicine out of the reach of children.

Sources

• https://www.drugs.com/drug-interactions/dorzolamide-timolol-ophthalmic,cosopt-pf.html
• https://www.drugs.com/drug-interactions/dorzolamide-timolol-ophthalmic,cosopt.html
• https://www.rxlist.com/cosopt-drug.htmhttps://www.elvium.ca/wp-content/uploads/COSOPT-EN-PM.pdf
• https://www.mayoclinic.org/drugs-supplements/dorzolamide-and-timolol-ophthalmic-route/description/drg-20061826
• https://pdf.hres.ca/dpd_pm/00057740.PDF
• https://www.webmd.com/drugs/2/drug-7707/dorzolamide-timolol-ophthalmic-eye/details
• https://www.rexall.ca/article/drug/view/id/1534

Generic name:	Dorzolamide/Timolol, Dorzolamide/Timolol
Formulation:	Eye Drops
Strength(s):	2/0.5%
Quantities Available:	5, 10, 15