Bonefos (Clodronate Disodium)

Do’s

• Take Bonefos exactly as prescribed by your healthcare provider. This includes the dosage (amount), frequency (how often you take it), and duration (for how long).
• Read the Patient Information Leaflet that comes with Bonefos. This will provide important information about side effects, drug interactions, and storage instructions.
• Take Bonefos on an empty stomach, with a full glass of water. This is usually at least two hours before a meal or any drinks except water.
• Sit upright or stand for at least 30 minutes after taking Bonefos. Avoid lying down or reclining to prevent heartburn.
• Maintain good dental hygiene. Bonefos can affect your jawbone, so see your dentist for regular checkups and cleanings.

Don'ts

• Do not take more Bonefos than prescribed by your healthcare provider.
• Do not take Bonefos if you are allergic to Pamidronate or any of the ingredients.
• Do not take Bonefos with milk, dairy products, calcium supplements, or mineral supplements. These can interfere with Bonefos' absorption.
• Do not take Bonefos with other medications without consulting your healthcare provider. This includes prescription and over-the-counter medications, as well as vitamins and herbal supplements.
• Do not crush, chew, or dissolve Bonefos tablets. Swallow them whole.
• Do not become pregnant or breastfeed while taking Bonefos. Discuss with your healthcare provider if you plan to become pregnant.

Common Side Effects:

• Gastrointestinal disturbances
• Hypocalcemia
• Flu-like symptoms
• Fever
• Fatigue
• Headache
• Bone pain
• Muscular pain
• Joint pain
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Rash
• Itching
• Dizziness
• Swelling of the ankles or feet
• Elevated liver enzymes

Serious Side Effects:

• Osteonecrosis of the jaw
• Atrial fibrillation
• Renal impairment
• Hypocalcemia
• Hypophosphatemia
• Hypomagnesemia
• Ocular inflammation
• Ocular pain
• Ocular hypertension
• Uveitis
• Scleritis
• Episcleritis
• Conjunctivitis
• Scleromalacia
• Corneal erosion
• Corneal opacity
• Corneal ulcer
• Scleral thinning
• Scleral melting
• Optic neuritis
• Optic neuropathy
• Optic atrophy
• Retinal vein occlusion
• Retinal artery occlusion
• Retinal detachment
• Retinal tear
• Macular edema
• Cystoid macular edema
• Papilledema
• Papillitis
• Papilloedema
• Choroidal effusion
• Choroidal detachment
• Choroiditis
• Chorioretinitis
• Iritis
• Vitritis

This is not an exhaustive list, and other side effects may occur. If you experience any unusual or severe side effects while taking Bonefos, contact your healthcare provider for medical advice.

Known allergy to clodronate or any other ingredients in Bonefos.

A diagnosed seizure disorder or a suspected increased risk of seizures.

Recently taken monoamine oxidase inhibitors (MAOIs). You should wait at least 14 days after stopping MAOIs before starting Bonefos treatment due to the potential for serious interactions.

Talk to your healthcare provider before using Bonefos if you have any of the following medical conditions:

• Heart problems: A history of heart attack, irregular heartbeat (arrhythmias), or other cardiovascular issues. Bonefos may affect heart rhythm.
• Kidney problems: Reduced kidney function can affect how your body processes Bonefos.
• Liver problems: This may affect how your body metabolizes Bonefos.
• Esophageal problems: A history of ulcers or inflammation in the esophagus (the tube connecting your throat to your stomach). Bonefos can irritate the esophagus.

Follow your healthcare provider's instructions carefully for taking Bonefos, including the dosage and administration method. Bonefos is usually taken with a full glass of water while sitting upright and remains upright for at least 30 minutes after taking it.

Do not lie down for at least 30 minutes and avoid eating food until after taking Bonefos.

Bonefos can decrease the absorption of other medications. Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal products. Your healthcare provider may need to adjust the timing of your medications.

Dental procedures: Inform your dentist that you are taking Bonefos before undergoing any dental procedures.

Pregnancy and Breastfeeding: Bonefos should only be used during pregnancy if clearly necessary. Discuss the risks and benefits with your healthcare provider. Bonefos may pass into breast milk, so consult your healthcare provider before breastfeeding while taking Bonefos.

Bonefos may weaken your bones with long-term use. Your healthcare provider will monitor your bone health with regular tests.